Undifferentiated Connective Tissue Disease (UCTD)

Author: Shelley Ensz. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer

When a person has symptoms of various connective tissue diseases without meeting the full criteria for any one of them, it is often called Undifferentiated Connective Tissue Disease (UCTD). (Also see Difficult Diagnosis)

Undifferentiated connective tissue disease at risk for systemic sclerosis (SSC): Which patients might be labeled prescleroderma? Predicting at onset which patients with Raynaud’s phenomenon are going to develop SSc over time has long been a research objective and still is an unaccomplished task. PubMed, Autoimmun Rev, 2020 Sep 14;102659.

Cardiac involvement in undifferentiated connective tissue disease (UCTD) at risk for systemic sclerosis (SSc) (otherwise referred to as very early–early systemic sclerosis): a TDI study. Our study shows that UCTD–risk–SSc patients show a previously unrecognized, mild biventricular systolic and diastolic dysfunction as compared to controls. PubMed, Clin Exp Med, 2018 May;18(2):237-243.

Anti-DFS70 autoantibodies in undifferentiated connective tissue diseases (UCTD) subjects: what's on the horizon? The high prevalence of anti-DFS70 antibodies in the UCTD patients suggested the potential role of these autoantibodies as a marker in the evolution of UCTD to CTD. PubMed, Rheumatology (Oxford), 04/03/2018. (Also see Antibodies)

Case Report: Primary anetoderma with undifferentiated connective tissue disease. The diagnosticuncertainty of this case led to added difficulty in management of a disease that is already notoriously difficult to treat and may significantly impact patient's quality of life. PubMed, Dermatol Online J.

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