Scleroderma in Overlap

Author: Shelley Ensz. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer
Overlap with Lupus
Overlap with Myopathies
Case Reports of Overlaps


When Systemic Sclerosis (in either the Limited or the Diffuse form) appears in conjunction with features of one or more other connective tissue diseases it is called "overlap." (Also see What is Scleroderma?)

Whole blood gene expression profiling distinguishes systemic sclerosis (SSc)-overlap syndromes from other subsets. Besides the two major subsets, limited and diffuse SSc, a substantial number of SSc cases exhibit overlap features of another rheumatic disease. PubMed, J Eur Acad Dermatol Venereol, 01/15/2020.

Scleroderma in Overlap with Lupus

Case Report: Scleroderma –associated thrombotic microangiopathy (TMA) in overlap syndrome of systemic sclerosis (SSc) and systemic lupus erythematosus (SLE). The occurrence of TMA leads to the deterioration of the prognosis of SSC-SLE overlap syndrome. PubMed, Medicine (Baltimore).

Assessing Systemic Lupus Erythematous (SLE)-Scleroderma (SSc) Combo — What are outcomes for patients with both conditions? Patients with SSc–SLE were equally likely to experience renal crisis, interstitial lung disease, or digital ulcers. Medpage Today, 10/20/2018. (Also see Lupus Media Stories)

Anti-neutrophil cytoplasmic antibody negative crescentic paucimmune glomerulonephritis in a case of scleroderma with systemic lupus erythematosus (SLE) overlap. In scleroderma and SLE overlap syndrome, the renal findings may vary being a combination of features of immune complex mediated glomerulonephritis as well as thrombotic microangiopathy. PubMed, Saudi J Kidney Dis Transpl.

Scleroderma in Overlap with Myopathies

Case Report: A case of overlap syndrome (scleroderma and polymyositis) associated with the development of sudden chest pain due to myocardial damage. Synthetic judgement of serum brain natriuretic peptide/ troponin T levels and cardiac MRI is useful in the search for the cause of chest symptoms even in patients with collagen diseases. PubMed, Drug Discov Ther, 2019;13(5):297-298. (Also see Cardiac (Heart) Involvement and Symptoms/Complications of Polymyositis)

Clinical and laboratory features of overlap syndromes (OS) of idiopathic inflammatory myopathies associated with systemic lupus erythematosus, systemic sclerosis, or rheumatoid arthritis. This is the first study to show the different characteristics of a series of patients with connective tissue disease (CTD)-OS in the heterogeneous Brazilian population. PubMed, Clin Rheumatol. (Also see Myopathy and Myositis, Lupus in Overlap and Rheumatoid Arthritis in Overlap)

Case Reports of Scleroderma in Overlap

(Case Report) Sclerodermiform linear lupus erythematosus: A distinct entity or coexistence of two autoimmune diseases? The coexistence of features of chronic cutaneous lupus erythematosus and scleroderma in the same skin lesions is very infrequent and has only been reported in 3 patients. Journal of the American Academy of Dermatology. (Also see Lupus)

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