Mixed Connective Tissue Disease (MCTD)

Author: Shelley Ensz. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer
MCTD and Scleroderma


Mixed Connective Tissue Disease is an overlap of clinical features of systemic lupus erythematosus, systemic sclerosis, and polymyositis, along with very high ribonucleoprotein autoantibodies, but without antibodies for other specific autoimmune diseases. (Also see Lupus, Systemic Sclerosis, Polymyositis, and Antibodies)

Mixed Connective Tissue Disease consists of the following core clinical and laboratory features: Raynaud phenomenon, swollen hands, arthritis/arthralgia, acrosclerosis, esophageal dysmotility, myositis, pulmonary hypertension, high level of anti-U1-RNP antibodies, and antibodies against U1-70 kd small nuclear ribonucleoprotein (snRNP). Medscape.

Case Report: Posterior reversible encephalopathy syndrome in a patient with mixed connective tissue disease. It is hard to accurately determine whether posterior reversible encephalopathy syndrome in this case is a complication of cyclophosphamide or a condition that resulted from the mixed connective tissue disease flare-up. BioMed Central, Journal of Medical Case Reports.


Case Report: Following leads: connecting dysphagia to mixed connective tissue disease. High–dose corticosteroids and methotrexate were given with little improvement, followed by intravenous immunoglobulin with progressive remission of symptoms. PubMed, BMJ Case Rep, 2018 Mar 5;2018.

Sensorineural hearing loss as a common manifestation in patients with mixed connective tissue disease. Raynaud's phenomenon, antiphospholipid and antiendothelial cell antibodies, increased serum levels of proinflammatory cytokines and a reduced number of regulatory T cells were found to be associated with sensorineural hearing loss in mixed connective tissue disease patients. International Journal of Clinical Rheumatology. (Also see Autoimmune Ear Disease)

(Case Report) Mixed connective tissue disease presenting as a peculiar myositis with poor muscle regeneration. Mixed connective tissue disease (MCTD) is a rheumatological disease which has to be distinguished from other entities causing inflammatory myopathy. Springerlink, Neurological Sciences. (Also see Myopathy)

Digital (Finger) Ulcer from Mixed Connective Tissue Disease (MCTD). This digital ulcer is 14 weeks old. It was caused by secondary Raynaud's phenomenon, in a patient with Mixed Connective Tissue Disease (MCTD). The MCTD was diagnosed 5 years ago, after thyroid gland removal. ISN Photo Repository, contributed by Jeanne N.

MCTD and Systemic Sclerosis (Scleroderma)

Clinical characteristics and survival in systemic sclerosis-mixed connective tissue disease (SSc-MCD) and systemic sclerosis-overlap (SSC-overlap) syndrome. This study provides insights into the clinical characteristics of patients with SSc-MCTD, SSc-overlap and SSc-only. PubMed, Arthritis Care Res (Hoboken), 02/14/2020.

Radiological images of interstitial pneumonia in mixed connective tissue disease (MCTD) compared with scleroderma (SSc) and polymyositis/dermatomyositis(PM/DM). HRCT images in MCTD patients can be classified as SSc pattern or PM/DM pattern. PubMed, Eur J Radiol, 2018 Oct;107:26-32. (Also see Correlation between Pulmonary Fibrosis and other Diseases and Dermatomyositis and Polymyositis)

Connective tissue diseases: systemic sclerosis: beyond limited and diffuse subsets? A new study now proposes that patients with systemic sclerosis and overlapping features of another connective tissue disease might form a distinct disease subset. PubMed, Nat Rev Rheumatol.

(Case Report) Scleroderma renal crisis in a newly diagnosed mixed connective tissue disease (MCTD) resulting in dialysis-dependent chronic kidney disease despite angiotensin-converting enzyme inhibition. A case of MCTD consisting of scleroderma, Sjögren's syndrome and polymyositis complicated by scleroderma renal crisis (SRC) but with negative anti-nuclear antibody (ANA), anti-Scl 70 and anti-centromere antibodies. Springerlink. (Also see Scleroderma Renal Crisis)

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