Patient and Caregiver Stories
Localized scleroderma affects the skin. It may also affect the underlying muscles and bones, but it does not reduce a person's life expectancy. (Also see What is Scleroderma? and Types of Scleroderma)
In general, localized scleroderma is relatively mild, and may be related to systemic scleroderma only in terms of similar superficial symptoms, such as the appearance of skin biopsy under the microscope.
sE-selectin, sIL-2R Levels Are Potential Markers of Localized Scleroderma Activity. Overall, the researchers suggested that both sE-selectin and sIL-2R are potential prognostic markers for localized scleroderma. Scleroderma News, 02/07/2019.
An extended high–frequency ultrasound protocol for assessing and quantifying of inflammation and fibrosis in localized scleroderma (LoS). High–frequency ultrasound allows an accurate assessment of the inflammatory and fibrotic skin lesions in LoS. PubMed, Skin Res Technol, 01/14/2019. (Also see Skin Fibrosis)
Comparison of 2-D shear wave elastography with clinical score in localized scleroderma (LS): A new method to increase the diagnostic accuracy. As non–invasive methods, mean shear wave velocity and dermal thickness by ultrasonography may provide reliable information to diagnose LS. PubMed, J Dermatol, 12/03/2018.
Linear scleroderma is a line of thickened skin which can affect the bones and muscles underneath it, thus limiting the motion of the affected joints and muscles. It most often occurs in the arms, legs, or forehead, and may occur in more than one area. ISN.
|Video Overview of Linear
En Coup de Sabre
|Parry Rombergs Syndrome
Sclerodermic Linear Lupus Panniculitis
Linear Patient Stories
Morphea scleroderma usually begins as patches of yellowish or ivory-colored rigid, dry skin. These then become hard, slightly depressed, oval-shaped plaques which usually have a whitish or yellowish center surrounded by a pinkish or purplish halo. ISN.
Types of Morphea
Causes of Morphea
Complications of Morphea
Patient and Caregiver Stories
Linear morphea scleroderma. Sometimes "morphea" is used as a generic term for localized scleroderma of any type. Thus, sometimes the term "linear morphea" refers to localized scleroderma of any type (either linear or morphea).
When "linear morphea" is used more literally, it means that there is a mixture of both types — linear and morphea, occurring together in combination.
Overview of Juvenile localized scleroderma (JLS) and its management. JLS is associated with a risk for disabling and disfiguring morbidity for the growing child. PubMed, World J Pediatr, 2020 Feb;16(1):5-18. (Also see Juvenile Scleroderma)
Systemic sclerosis (SSc) complicated with localized scleroderma-like (Lsc) lesions induced by Köbner phenomenon. The epidermis of SSc patients with LSc-like lesions seems to possess an inflammatory phenotype, leading to the activation of mast cells in the dermis of mechanically stressed skin. PubMed, J Dermatol Sci, 2018 Mar;89(3):282-289. (Also see Linear Scleroderma)
Prospective study to evaluate the clinical and radiological outcome of patients with scleroderma of the face. Patients with localized scleroderma of the face have a high prevalence of neurological and ophthalmological changes. All cases of localized scleroderma of the face should be thoroughly examined for the presence of systemic changes. PubMed. (Also see Eye Involvement, and Neurological Involvement)
Localized Scleroderma: MR (magnetic resonance) Findings and Clinical Features. The purpose of this study was to describe musculoskeletal manifestations seen at magnetic resonance (MR) imaging in patients with localized scleroderma (LS) and to examine the relationship of MR findings to clinical subtypes and clinically suspected musculoskeletal features. Schanz S. (PubMed) Radiology.
Collagen Degradation Products And Elastin In Systemic (SSc) And Localized Scleroderma (lSSc) . Increased markers of collagen and elastin turnover in SSc and LSc reflect the active fibrotic process in the diseases and are accordance with the published data. High elastin levels in psoriasis vulgaris group are rather difficult to explain. PubMed, Folia Biol (Praha).
Juvenile Scleroderma by ISN.
SCLERO.ORG is the world's leading nonprofit for trustworthy research, support, education and awareness for scleroderma and related illnesses. We are a 501(c)(3) U.S.-based public charitable foundation, established in 2002. Meet Our Team. Donations may also be mailed to: