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Statins

Medications for Scleroderma, Arthritis, Autoimmune and Rheumatic Diseases

Author: Janey Willis. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer

Statins are a class of drugs that lower the level of cholesterol in the blood by reducing the production of cholesterol by the liver. Recent findings have shown statins to offer some relief to patients with scleroderma and other rheumatic diseases. (Also see What is Scleroderma?, Medical Overview, and Medications for Scleroderma, Arthritis, Autoimmune and Rheumatic Diseases)

Diagnosis of osteoporosis in statin-treated patients is dose-dependent. The diagnosis of osteoporosis in statin-treated patients is dose-dependent, demonstrating the importance of future studies' taking dose-dependency into account. PubMed, Ann Rheum Dis, 2019 Dec;78(12):1706-1711. (Also see Osteoporosis)

The effect of statin use on mortality in systemic autoimmune rheumatic diseases (SARD). In this study, statin initiation was shown to reduce overall mortality in patients with SARD after adjusting for relevant determinates of cardiovascular disease risk. PubMed, J Rheumatol, 2018 Dec;45(12):1689-1695.

Statin–related myopathies. Statin–induced immune–mediated necrotising myopathy represents a novel disease mechanism and clinically mimics forms of myositis. PubMed, Pract Neurol, 2018 Apr;18(2):97-105. (Also see Myopathy and Myositis)

Statins Inhibit Cytokines in a Dose–Dependent Response in Patients with Systemic Sclerosis (SSc). Statins, particularly simvastatin, appear to have an immunosuppressive effect in reducing all cytokine secretion levels from peripheral blood mononuclear cells of SSc in a dose–dependent manner. PubMed, Inflammation, 10/04/2018. (Also see Cytokines)

Scleroderma Treatments and Clinical Trials ISN.

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