NSAIDs, Anti-Inflammatories, Pain Medications

Medications for Scleroderma, Arthritis, Autoimmune and Rheumatic Diseases

Author: Janey Willis. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer
Overview of NSAIDs
Possible Side Effects
FDA Warnings
NSAIDS and Cancer
Cox-2 Inhibitors

Overview of NSAIDs

Interestingly, opiates — like codeine or morphine — are much safer for long term use than NSAIDs for the elderly, or for people with chronic illness.

Nonsteroidal anti-inflammatory drugs (NSAIDs) can help relieve pain.

Even though they are available over-the-counter, that does not mean that they are harmless, nor that they should be taken for more than a brief period (as stated on the label) without consulting a doctor.

Often there are safer or more effective alternatives, and sometimes their use masks issues that need more medical attention.

Side effects of NSAIDs can include increased risk of asthma, dementia, and internal bleeding. Except for aspirin, NSAIDs also increase the risk of heart attack, stroke, and heart failure.

Experts advise that the elderly and people with chronic illnesses should first try acetomenophen, but to never take more than the safe amount listed on the container, because even slight overdoses can cause liver failure and death.

If NSAIDs do not work, then opiates (like codeine or morphine) are much safer for long term use. (Also see What is Scleroderma?, Medical Overview, and Medications for Scleroderma, Arthritis, Autoimmune and Rheumatic Diseases)

An Aspirin a Day for Heart Health? It May Depend on Your Weight. A daily dose of baby aspirin is widely recommended for heart disease prevention, but a one–dose–fits–all approach may not work. New York Times, 07/17/2018.

Information for Patients About NSAIDs. Traditional NSAIDs include aspirin, ibuprofen (e.g., Advil, Motrin), naproxen (e.g., Aleve) and many other generic and brand name drugs. A newer addition to the NSAID group is celecoxib (Celebrex) which is a COX 2 Selective NSAID. American College of Rheumatology.

Nonsteroidal anti-inflammatory drugs (NSAIDs). Non Steroidal Anti-Inflammatory Drugs (NSAIDs) are medications which, as well as having pain-relieving (analgesic) effects, have the effect of reducing inflammation when used over a period of time.

Scleroderma Treatments and Clinical Trials ISN.

Possible Side Effects of NSAIDs

NSAIDs. Dosage, Side Effects, Drug Interactions, Warnings. VeryWell.

Taking an aspirin each day does more HARM than good for healthy middle-aged adults. A major new study concludes the risk of major internal bleeding significantly outweighs the benefit of aspirin among those with no history of heart disease. Mail Online, 01/22/2019.

FDA and Other Warnings about NSAIDs

Heart attack, stroke warning on pain relievers strengthened. Prescription and over-the-counter NSAIDs were found in several studies to increase the risk for heart attack and stroke, prompting the Food and Drug Administration to strengthen warnings on bottles and boxes. United Press International.

NSAIDs and Cancer

Use of non-steroidal anti-inflammatory drugs and prostate cancer risk: a population-based nested case-control study. Our findings suggest modest benefits of at least some NSAIDs in reducing prostate cancer risk. Mahmud SM. PLoS One.

Cox-2 Inhibitors

COX-2 inhibitors are a form of non-steroidal anti-inflammatory drug (NSAID) that directly targets COX-2, an enzyme responsible for inflammation and pain. Celebrex and Vioxx are Cox-2 inhibitors.

Cox-2 Inhibitors. The COX-2 inhibitors represent a new class of drugs that do not affect COX-1, but selectively block only COX-2. This selective action provides the benefits of reducing inflammation without irritating the stomach.

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