Vascular in Scleroderma
Types in Scleroderma
In Other CTDs
The vascular system is our circulatory system. It consists of all the vessels that carry blood and lymph through the body, to and from organs. Vessels include arteries, veins, and capillaries. Any condition that affects the vascular system, all of in part, is considered a vascular disease.
Systemic sclerosis (scleroderma) can affect any or every part of the body, including the circulatory system (vascular system). Problems in the circulatory system can cause heart problems, Raynaud's, Watermelon Stomach, and even vascular headaches. (Also see What is Scleroderma?, Raynaud's, and Watermelon Stomach)
The Heart and Vascular Disease. Vascular disease includes any condition that affects the circulatory system. Vascular disease ranges from diseases of your arteries, veins, and lymph vessels to blood disorders that affect circulation. WebMD.
Vascular disease in scleroderma can be widespread throughout the body. In effect, vascular disease can affect any organ or any part of the body by affecting the circulation of blood to and from or within. Examples are Raynaud's Phenomenon, Pulmonary Arterial Hypertension, and Renal Involvement. (Also see What is Scleroderma? and Types of Scleroderma)
Arterial stiffness correlates with progressive nailfold capillary microscopic changes in systemic sclerosis (SSc): results from a cross-sectional study. These data suggest that arterial stiffness correlates with microvascular damage in patients with SSc. PubMed, Arthritis Res Ther, 2019 Nov 27;21(1):253. (Also see Nailfold Capillaroscopy)
Association of simple hematological parameters with disease manifestations, activity, and severity in patients with systemic sclerosis (SSc). Globally available and inexpensive hematological tests, may be associated with vascular and cutaneous manifestations as well as disease activity and severity in SSc. PubMed, Clin Rheumatol, 07/18/2019.
Ulnar Artery Occlusion (UAO) and severity markers of vasculopathy in Systemic sclerosis (SSc): a multicenter cross–sectional study. UAO may represent a relevant severity marker of the vasculopathy in SSc. PubMed, Arthritis Rheumatol, 12/15/2018.
Correlations between blood perfusion (BP) and dermal thickness (DT) in different skin areas of systemic sclerosis (SSc) patients. This study demonstrates for the first time in SSc patients a significant inverse relationship between skin BP, measured by laser speckle contrast analysis, and DT, evaluated by both ultrasound and modified Rodnan skin score (mRSS), at the level of dorsum of the middle phalanx of the third fingers. PubMed, Microvasc Res, 2018 Jan;115:28-33. (Also see Skin Fibrosis)
Prevalence of macrovascular arterial involvement of the 4 limbs in systemic sclerosis (SSc): About a case series of 14 patients. It seems necessary that SSc patients have a strict balance of their cardiovascular risk factors (CVRF) and a screening of macrovascular arterial lesions. PubMed, Rev Med Interne. 2017 Jul;38(7):430-435.
Nailfold capillaroscopic (NVC) parameters and skin telangiectasia patterns in patients with systemic sclerosis. The severity of nailfold microangiopathy seems to correlate in SSc patients with both progressive cutaneous microvascular abnormalities and Medsger's severity score, as evaluated by NVC analysis and dermoscopy. PubMed, Microvasc Res, 2017 May;111:20-24. (Also see Nailfold Videocapillaroscopy and Telangiectasia)
Exercise–induced brachial artery blood flow and vascular function is impaired in systemic sclerosis (SSc). Vascular dysfunction in the patients with SSc was accompanied by elevated blood markers of oxidative stress and attenuated endogenous antioxidant activity. PubMed, Am J Physiol Heart Circ Physiol, 2016 Dec 1;311(6):H1375-H1381.
Vascular stiffness mechanoactivates YAP/TAZ–dependent glutaminolysis to drive pulmonary hypertension. These results indicate that extracellular matrix stiffening sustains vascular cell growth and migration through YAP/TAZ-dependent glutaminolysis and anaplerosis, and thereby link mechanical stimuli to dysregulated vascular metabolism. PubMed, J Clin Invest, 2016 Sep 1;126(9):3313-35.
Autoantigens targeted in scleroderma patients with vascular disease are enriched in endothelial lineage cells. Expression of scleroderma autoantigens IFI16 and CENPs, which are associated with severe vascular disease, is increased in vascular progenitors and mature endothelial cells. PubMed, 05/09/2016.
Autoantigens targeted in scleroderma patients with vascular disease are enriched in endothelial lineage cells. Expression of scleroderma autoantigens IFI16 and CENPs, which are associated with severe vascular disease, is increased in vascular progenitors and mature endothelial cells. PubMed, Arthritis Rheumatol, 05/09/2016.
Risk of Digital Vascular Events in Scleroderma Patients Who Have Both Anticentromere and Anti-Interferon-Inducible Protein 16 Antibodies. Scleroderma patients who are double–positive for antibodies recognizing CENP and IFI-16 are significantly more likely to have significant digital vascular events during the course of their disease. PubMed, Arthritis Care Res (Hoboken), 2017 Jun;69(6):922-926. (Also see Antibodies and Digital Ulcers)
Systemic Scleroderma Cardiac (Heart) Involvement. Vascular disease and the heart involves the blood vessels to and from the heart. Carotid artery disease, atherosclerosis, and stroke are types of vascular disease that can affect the heart. ISN.
Carotid Artery Disease
Stroke and TIA
Gastric Antral Vascular Ectasia (GAVE). Watermelon Stomach is the popular name for Gastric Antral Vascular Ectasia (GAVE) — a condition in which the lining of the stomach bleeds, causing it to look like the characteristic stripes of a watermelon when viewed by Endoscopy. ISN
|What is Watermelon Stomach?
|A Patient's Perspective
Watermelon Stomach in Associated with Other Diseases
Pulmonary Arterial Hypertension. Pulmonary Hypertension is not the same as "regular" high blood pressure or hypertension, which can be easily measured with a blood pressure test. ISN.
Exercised Induced PH
Raynaud's Phenomenon. Raynaud's is a vascular disease commonly found in sclerodema. The fingers and/or toes become white and/or blue, and may become red on re-warming. ISN.
Tips from Patients
Vascular manifestations of systemic lupus erythematosis. Awareness of the aetiology, pathophysiology, the clinical and histopathogical setting, and SLE-associated vascular complications is of great clinical significance. Neth J Med. (Also see Lupus)
Angiogenic and angiostatic factors in renal scleroderma (SSc)-associated vasculopathy. This is the first study that assess in SSc patients intrarenal hemodynamic parameters and endostatin and in SSc patients, endostatin represents a marker of renal scleroderma-associated vasculopathy. PubMed, Microvasc Res, 2017 Nov;114:41-45.
Defining a unified vascular phenotype in systemic sclerosis. The more recent biomarker longitudinal studies support the concept of generalized vasculopathy and a potential association between various cardiovascular complications. PubMed, Arthritis Rheumatol, 11/16/2017. (Also see Digital Ulcers)
Serum levels of genomic DNA of α1(I) collagen are elevated in scleroderma patients. In summary, elevation of serum α1(I) collagen DNA levels in scleroderma patients may be useful as the diagnostic marker, reflecting the presence of vasculopathy. PubMed, J Dermatol, 03/31/2017.
Angiogenesis. A tumor consists of cells that are dividing at an abnormally high rate, crowding surrounding healthy cells and competing for resources. BioInteractive.
Decreased CCN3 in Systemic Sclerosis endothelial cells contributes to impaired angiogenesis. CCN3 may represent a promising therapeutic target for SSc patients presenting with vascular involvement. PubMed, J Invest Dermatol, 01/16/2020.
The "myth" of loss of angiogenesis in systemic sclerosis: a pivotal early pathogenetic process or just a late unavoidable event? We suggest the loss of angiogenesis should not be considered as an overall "myth" characterizing systemic sclerosis, but as a very late event of the vascular pathogenesis. PubMed, Arthritis Res Ther, 2017 Jul 6;19(1):162.
Hypoxia (Medical). Hypoxia is a pathological condition in which the body as a whole (generalized hypoxia) or a region of the body (tissue hypoxia) is deprived of adequate oxygen supply. Wikipedia.
The role of endothelial cells (EC) in the vasculopathy of systemic sclerosis (SSc): A systematic review. This systematic review emphasizes the growing evidence that SSc is primarily a vascular disease where EC dysfunction is present and prominent in different aspects of cell survival. PubMed, Autoimmun Rev, 05/29/2017.
Nailfold videocapillaroscopy (NVC) and serum VEGF levels in scleroderma (SSc) are associated with internal organ involvement. Our data suggest the importance of NVC for the diagnosis of SSc patients and serum VEGF levels may act as a biomarker of interstitial lung involvement. PubMed, Auto Immun Highlights. 2016 Dec;7(1):5.
Vitamin D in Vascular Calcification (VC): A Double-Edged Sword? This review addresses the current understanding of VC pathophysiology, with a focus on the pathogenic role of vitamin D that has provided new insights into the mechanisms of VC. PubMed, Nutrients. 2018 May 22;10(5). (Also see Vitamin D)
Help brains by cooling bodies after cardiac arrest. People who are left unconscious after their heart suddenly stops should be cooled in an effort to preserve brain function, according to the American Academy of Neurology. Reuters Health, 05/12/2017.
IgG4-Associated Vasculitis. Clinicians must be aware that the clinical manifestations of IgG4-RD and anti-neutrophil cytoplasmatic antibodies (ANCA)-associated vasculitis may overlap. PubMed, Curr Rheumatol Rep.
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