Bone Resorption in Systemic Sclerosis (SSc/Scleroderma)

Dental Involvement


Bone resorption may occur anywhere in systemic scleroderma, but it most commonly occurs in the fingertips and mandible (lower jaw). The bones at the tips of the fingers may be reabsorbed into the body. When bone resorption affects the jaw, it can cause teeth to loosen and may also be associated with microstomia (the mouth becoming smaller.) (Also see What is Scleroderma?, Skeletal Involvement, Hand and Joint Involvement, Osteoporosis, Dental Involvement, and Microstomia)

Osteoporosis occurs when the rate of bone resorption exceeds the rate of bone formation creating "porous bones." Most cases of osteoporosis occur as an acceleration of this normal aging process. The condition can also be caused by other disease processes or prolonged use of certain medications that result in bone loss. (Also see Osteoporosis)

Bone Resorption of the Mandible (Lower Jaw). Scleroderma can loosen teeth by causing the ligament around the teeth to expand due to collagen deposition. When the ligament expands, the teeth are less supported by bone structure. Dental implants work well in these instances. ISN


Acroosteolysis or bony resorption of the terminal digital tufts, is a well-recognized, but under-researched, feature of systemic sclerosis. PMC, Exp Ther Med.

Case Report: Acro–osteolysis and calcinosis in patient with scleroderma. We present a unique case of progressive acro–osteolysis of the distal phalanges and articular calcifications in a patient with scleroderma. PubMed, Acta Orthop Traumatol Turc. (Also see Calcinosis)

Late nailfold videocapillaroscopy (NVC) patterns associated with hand calcinosis and acro-osteolysis in systemic sclerosis (SSc). Acro–osteolysis and calcinosis are independently associated with the late NVC pattern, and particularly with severe capillary loss. PubMed, Arthritis Care Res (Hoboken). (Also see Calcinosis and Nailfold videocapillaroscopy)

Dental Involvement in Systemic Sclerosis (Scleroderma)

Dental Involvement in Systemic Sclerosis (SSc). Scleroderma can cause numerous dental problems when it affects the face and mouth. Skin tightening can cause the mouth to become smaller (microstomia), as well as TMJ and trigeminal neuralgia. ISN.

Bone Resorption
Candida (Fungal)
Dental Amalgam
Dental Fears/Phobias
Dental Implants
General Dentistry
Microstomia (Small Mouth)
Microstomia Stories
Mouth Sores
Periodontal Disease
Photos of Dental Involvement
Scleroderma Dental
Sensitive Teeth
Stories of Scleroderma Dental
Sjogren's Syndrome
Taste and Smell
Tongue and Oral Cancers
Trigeminal Neuralgia
Xerostomia (Dry Mouth)

Causes of Bone Resorption

PSTP-3,5-Me Inhibits Osteoclast Differentiation and Bone Resorption. Our data suggests that PSTP-3,5-Me attenuates osteoclast differentiation by blocking the activation of NFATc1. PubMed, Molecules. 2019 Sep 14;24(18).

Anti–HMGB1 neutralizing antibody attenuates periodontal inflammation and bone resorption in a murine periodontitis model. These findings indicate that high mobility group box 1 (HMGB1) is secreted in response to inflammatory stimuli caused by periodontal infection, which is crucial for the initiation of periodontitis. PubMed, Infect Immun, 03/12/2018. (Also see Periodontal Disease)


Autophagy in fate determination of mesenchymal stem cells (MSC) and bone remodeling. This review aims to summarize the up-to-date knowledge about the effects of autophagy on MSC fate determination and its role as a stress adaptation response. PubMed, World J Stem Cells, 2020 Aug 26;12(8):776-786.

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