Scleroderma Types Systemic Symptoms Raynaud's

Raynaud's Research

Raynaud's Research

Glycolysis-derived acidic microenvironment as a driver of endothelial dysfunction in systemic sclerosis. This study disclosed a liaison among the metabolic reprogramming of SSc dermal fibroblasts, extracellular acidosis and endothelial dysfunction that may contribute to the impairment and loss of peripheral capillary networks in SSc disease. PubMed, Rheumatology (Oxford), 2021 Jan 20;keab022.

Vascular acrosyndromes in young adult population. Definition of clinical symptoms and connections to joint hypermobility. Erythromelalgia is the commonest functional vasculopathy in young population followed by acrocyanosis and a combination of these conditions. PubMed, Clin Rheumatol, 2019 Oct;38(10):2925-2932.

Clinical Trials

Performance of laser-derived imaging for assessing digital perfusion in clinical trials of systemic sclerosis (SSc)-related digital vasculopathy: A systematic literature review. Full-field perfusion of the digits (with/without provocation testing) is a promising clinical trial outcome measure for trials of SSc-related digital vasculopathy. PubMed, Semin Arthritis Rheum, 2020 Oct;50(5):1114-1130.

The Role of Nitric Oxide in Raynaud's

Serum nitric oxide (NO) metabolites and disease activity in patients with systemic sclerosis. Serum NO(x) in SSc patients were elevated compared to healthy controls. Serum NO(x) level was determined by multiple factors including age, prednisolone use, and elevated pulmonary arterial pressure. (PubMed) Clin Rheumatol.

Raynaud's Studies

Digital (Finger and Toe) Ulcers. ISN.
Gangrene and Amputations. ISN.
Scleroderma Clinical Trials. ISN.
Scleroderma Research Registries. ISN.

SCLERO.ORG is the world's leading nonprofit for trustworthy research, support, education and awareness for scleroderma and related illnesses. We are a 501(c)(3) U.S.-based public charitable foundation, established in 2002. Meet Our Team. Donations may also be mailed to: