SCLERO.ORG
Search

Complications with Systemic Scleroderma (SSc) Heart Involvement

Author: Shelley Ensz. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer
Overview
Aneurysms
Aortic Valve Insufficiency
Arrhythmia
Arterial Stiffness
Atrioventricular Heart Block
Cardiogenic Shock
Cardiac Tamponade
Diastolic Dysfunction
Macrovascular Disease
Myocardial Infarction
Skeletal Myopathy

Overview of Cardiac Complications with SSc

Systemic sclerosis might be a vascular disease, which begins by targeting blood vessels.

Photo of butterfly needleComplications with systemic sclerosis (scleroderma) heart involvement include atrioventricular heart block, cardiogenic shock, myocardial infarction, and skeletal myopathy. (Also see What is Scleroderma?, Types of Scleroderma, Symptoms of Scleroderma, and Overview of Cardiac Involvement)

Doppler myocardial imaging (DMI) can identify patients with a more diffuse and severe form of scleroderma, ideally before they develop severe vascular problems. (Also see Diagnosis of Scleroderma Cardiac Involvement)

Late Gadolinium Enhancement (LGE) in Cardiac Magnetic Resonance Imaging Is Associated with High Renal Resistive Index (RRI) in Patients with Systemic Sclerosis. Our study, showed RRI and LGE as markers of vascular and fibrotic damage. PubMed, Kidney Blood Press Res, 2020;45(2):350-356. (Also see Kidney Involvement)

Aneurysms

Aortic Aneurysms. Approximately 95 percent of aortic aneurysms are caused by atherosclerosis. Diseases that cause aortic aneurysms include Marfan syndrome, Loeys-Dietz Syndrome, Turner's Syndrome, and Scleroderma. Johns Hopkins Medicine. (Also see What is Scleroderma?)

Aortic Valve Insufficiency

Aortic valve insufficiency in patients with chronic rheumatic diseases. Patients with rheumatic disease as a potential aetiology (cause) of aortic valve insufficiency often had symptomatic valve disease, which required surgical treatment, although great differences between different aetiologies were not found. Uusimaa P. (PubMed) Clin Rheumatol.

Arrhythmias, Palpitations, and Conduction Disturbances

What is Arrhythmia? General Physician Home.

Electrocardiographic markers for the prediction of ventricular arrhythmias in patients with systemic sclerosis. The question is whether certain ECG parameters reflecting ventricular repolarization may help to recognize scleroderma patients with increased risk for ventricular arrhythmias and sudden cardiac death. PubMed, Rheumatology (Oxford), 01/14/2020.

Cardiac magnetic resonance predicts ventricular arrhythmias in scleroderma (SSc): the Scleroderma Arrhythmia Clinical Utility Study (SanCtUS). Ventricular function, oedema (T2 ratio) and %late gadolinium enhancement had the greatest utility as independent predictors of rhythm disturbances in SSc patients. PubMed, Rheumatology (Oxford), 11/25/2019.

Childhood smoking exposure tied to irregular heartbeat in adulthood. Children who grow up breathing their parents’ secondhand smoke are more likely to develop a heart rhythm disorder known as atrial fibrillation than the kids of nonsmokers, a recent study suggests. Reuters Health, 09/26/2019.

Incidental significant arrhythmia in scleroderma (SSc) associates with cardiac magnetic resonance measure of fibrosis and hs-TnI and NT-proBNP. This first implantable loop recorder study identified potentially life–threatening arrhythmias in asymptomatic SSc patients attributable to a primary SSc heart disease. PubMed, Rheumatology (Oxford), 01/28/2019.

Improving overall heart health may reduce risk of atrial fibrillation. Following practices recommended for “optimal” heart health may also reduce the risk of developing a serious heart–rhythm disorder, researchers say. Reuters Health, 04/19/2018.

Arterial Stiffness

Percutaneous coronary intervention (PCI) outcomes in patients with rheumatoid arthritis, systemic lupus erythematosus (SLE) and systemic sclerosis (SSc). We demonstrate increased rates of all adverse clinical outcomes following PCI in people with SSc and increased bleeding in SLE. PubMed, Rheumatology (Oxford), 01/28/2020.

Atrioventricular Heart Block

Case Report: Complete heart block (CHB) in systemic sclerosis (SSc). Pacemaker implantation might be unavoidable if CHB is secondary to SSc, even if it is asymptomatic. PubMed, Medicine (Baltimore), 2018 Nov;97(46):e13226.

Third-Degree Atrioventricular Block. Heart block occurs when slowing or complete block of this conduction occurs. Traditionally, heart block can be divided into first-, second-, and third-degree block. eMedicine.

Cardiogenic Shock

Cardiogenic shock is a condition in which your heart suddenly can't pump enough blood to meet your body's needs. The condition is most often caused by a severe heart attack. Mayo Clinic.

Cardiac Tamponade

Cardiac tamponade. Cardiac tamponade is the compression of the heart caused by blood or fluid accumulation in the space between the myocardium (the muscle of the heart) and the pericardium (the outer covering sac of the heart). Medline Plus.

Diastolic Dysfunction

What is diastolic dysfunction? Diastolic dysfunction is abnormal function of the heart during its relaxation phase, between beats, called diastole. While the heart's ability to contract and pump blood may be maintained, its ability to relax and fill with blood is compromised. Sharecare.

Cardiac Function in Patients With Polymyositis (PM) or Dermatomyositis (DM): A Three-Dimensional Speckle-Tracking Echocardiography Study. Our results suggest that cardiac injury in PM/DM is a long-term process and its severity depends on patients' heterogeneous clinical features and systemic disease burden. PubMed, Int J Cardiovasc Imaging, 2018 May;34(5):683-693. (Also see Dermatomyositis and Polymyositis)

Macrovascular Disease

Evaluation of differences in carotid intima–media thickness in patients affected by systemic rheumatic diseases. Systemic sclerosis (SSc) patients had a significant increase in C-IMT as compared to NoSSc patients and healthy controls. PubMed, Intern Emerg Med.

Myocardial Infarction

A myocardial infarction is a heart attack. It occurs when the blood supply to part of the heart muscle itself (the myocardium) is severely reduced or stopped. Primary myocardial involvement is common in systemic sclerosis.

Nearly half of U.S. adults don't recognize some heart attack symptoms. Nearly half of Americans might not realize they are having a heart attack because they are not familiar with some of the symptoms, a new study suggests. Reuters Health, 12/18/2019.

FDA approves fish-oil drug for cutting cardiac risks. U.S. regulators approved expanded use of a fish oil-based drug for preventing serious heart complications in high-risk patients already taking cholesterol-lowering pills. NBC Health News, 12/13/2019. (Also see Supplement Guide)

Case Report: Complete heart block in systemic sclerosis (SSc). The occurrence of heart block associated with SSc often appears concealed and the case highlights the importance of regular follow-up of a patient with SSc. PubMed, Medicine (Baltimore).

Skeletal Myopathy

Elevated Cardiac Troponin T (cTnT) in Patients With Skeletal Myopathies. Measured cTnT concentrations were chronically elevated in the majority of patients with skeletal myopathies, whereas cTnI elevation was rare. PubMed, J Am Coll Cardiol, 2018 Apr 10;71(14):1540-1549. (Also see Myositis)

Go to Diagnosis of Scleroderma Heart Involvement
 
 

SCLERO.ORG is the world's leading nonprofit for trustworthy research, support, education and awareness for scleroderma and related illnesses. We are a 501(c)(3) U.S.-based public charitable foundation, established in 2002. Meet Our Team. Donations may also be mailed to:

International Scleroderma Network (ISN)
7455 France Ave So #266
Edina, MN 55435-4702 USA
Email [email protected]. Disclaimer. Privacy Policy.