Lipodystrophy or Lipoatrophy

Author: Shelley Ensz. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer
Semicircular Localized Lipodystrophy
This page covers only localized lipodystrophy which is caused by autoimmune diseases. Other causes include AIDS/HIV or retroviral treatments.


Lipodystophy KaleidoscopeLipodystrophy (or lipoatrophy) refers to a loss of fat tissue. It can be localized, partial, or total.

Types of Lipodsytrophies. There are several different types of lipodystrophies and the degree of fat loss may vary from very small depressed areas to near complete absence of adipose tissue. Inherited lipodystrophies are caused by mutations in a gene. Acquired lipodystrophies are caused by medications, autoimmune mechanisms or other unknown mechanisms. Southwestern Medical Center.


Localized Lipodystrophy. Because localized lipodystrophy is extremely rare, only a few case series of lipodystrophic syndromes are reported in the literature. Emedicine.

Semicircular Localized Lipodystrophy or Lipoatrophy

Semicircular Localized Lipodystrophy. Lipoatrophy can be a common sequela of panniculitis in patients with connective tissue diseases (eg, systemic lupus erythematosus, subcutaneous morphea, the syndrome of lobular lymphocytic connective tissue panniculitis of Winkelmann and Padilha-Goncalves). Lipoatrophy can be associated with nephritis, hypocomplementemia, scleroderma, Sjögren syndrome, recurrent pyogenic infections, immune thrombocytopenic purpura (ITP), and thyroiditis. Medscape.

Lipoatrophia Semicircularis: a new office disease? 900 cases reported in Belgium. This phenomenon was reported for the first time in three patients in 1974 by Gschwandtner and Munzberger. Since then, there have been some publications, but these relate only to 70-odd patients. Since 1995, we have diagnosed more than 900 cases in our company. Although the cause is still unknown, we believe that electromagnetic fields play an important role in this phenomenon. ESD Journal.


Lipodystrophy, Progressive: Differential Diagnoses & Workup. Urinalysis, baseline creatinine and blood urea nitrogen studies, as well as urine studies, a CBC count, and other tests are recommended for lipodystrophy. Medscape.

Apolipoprotein CIII and Angiopoietin-like Protein 8 are Elevated in Lipodystrophy and Decrease after Metreleptin. Elevations in lipoprotein lipase inhibitors apoC-III and ANGPTL8 may contribute to hypertriglyceridemia in lipodystrophy, and may mediate reductions in circulating and hepatic triglycerides after metreleptin. PubMed, J Endocr Soc, 2020 Dec 4;5(2):bvaa191.


Causes of Lipodystrophy, other than HIV/Aids and retroviral treatment, include autoimmune diseases, dermatomyositis, diabetes, electromagnetic fields, gluten sensitivity, lupus, panniculitis, scleroderma, Sjogren's, and thyroiditis. ISN.

Electromagnetic Fields?
Gluten Sensitivity
Sjogren's Syndrome

Treatments for Lipodystrophy

Myalept. Myalept is a leptin replacement prescription medicine used along with a doctor-recommended diet for people with generalized lipodystrophy (GL). Myalept treats problems caused by not having enough leptin in the body (leptin deficiency). Aegerion Pharmaceuticals.

Go to Causes of Lipodystrophy

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