Hello, I am | Scleroderma Medical News by Date | |
| July 2009 | |
| The transport of high amounts of vascular endothelial growth factor (VEGF) by blood platelets underlines their potential contribution in systemic sclerosis angiogenesis. Platelets transport high levels of VEGF in SSc. They may contribute to circulating VEGF because of ongoing activation in the course of the disease. If activated at the contact of injured endothelium, platelets may be important in the altered angiogenesis associated with the disease through the secretion of high levels of VEGF. Anne Solanilla. Rheumatology June 23, 2009. (Also see: VEGF) | |
| Serum Vascular Endothelial Growth Factor (VEGF) levels are related to the presence of pulmonary arterial hypertension (PAH) in systemic sclerosis. Serum VEGF levels are increased in systemic sclerosis patients with systolic pulmonary artery pressure(sPAP) ≥ 35 mmHg. The correlation between VEGF levels and sPAP may suggest a possible role of VEGF in the pathogenesis of PAH in systemic sclerosis. Andriana I Papaioannou. BMC Pulmonary Medicine 2009, 9:18. (Also see: VEGF and Pulmonary Hypertension) | |
| Expression of advanced glycation end products and their receptor in skin from patients with systemic sclerosis (SSc) with and without calcinosis. Our results indicate the possible contribution of AGE-CML [N{epsilon}-(carboxymethyl) lysine] deposition on the extracellular matrix in the dermis of the limited SSc with extracellular matrix subgroup to the pathogenesis of formation of calcinotic deposits. Christine A. Davies. Rheumatology. June 19, 2009. (Also see: Calcinosis) | |
| Lack of Specificity of the 6-Minute Walk Test as an Outcome Measure for Patients with Systemic Sclerosis. The 6MWD relates to broad factors in SSc and these results raise doubts about the specificity of the 6MWD in this systemic disease, and its relevance to monitoring therapy. Yoland Schoindre. The Journal of Rheumatology. vol. 36 no. 7 1481-1485. July 2009. (Also see: Pulmonary Fibrosis and Pulmonary Hypertension) | |
| Cerebral Vasculopathy Is Associated with Severe Vascular Manifestations in Systemic Sclerosis. Severe cerebral vasculopathy is associated with severe vascular manifestations in SSc patients. SSc patients with severe vascular complications should undergo neuroradiological imaging assessment of brain involvement. Benjamin Terrier. The Journal of Rheumatology. vol. 36 no. 7 1486-1494. July 2009. (Also see: Brain Involvement and Vascular Involvement) | |
| Systolic and diastolic function in patients with systemic sclerosis. The analysis of SSc heart disease, mainly at a preclinical level, is important in all the cases as an asymptomatic patient may have diastolic dysfunction which can be treated and should be closely observed. Laura Poanta. European Journal of Internal Medicine. Volume 20, Issue 4, Pages 378-382 (July 2009). (Also see: Heart (Cardiac) Involvement) | |
| Ascertainment of collagen vascular disease in patients presenting with interstitial lung disease.Unrecognized collagen vascular disease may be more common than previously appreciated among patients referred with ILD. High titer ANA and an elevated CPK or aldolase are associated with a CVD diagnosis in this referral population.Shikhaa Mittoo. Journal of Respiratory Medicine. Volume 103, Issue 8, Pages 1152-1158. (August 2009). (Also see: Pulmonary Fibrosis) | |
| Prognostic factors for lung function in systemic sclerosis: prospective study of 105 cases. To identify prognostic factors for SSc-ILD and to clarify the possible causative role of manometric esophageal involvement. Only diffuse SSc was predictive of a decrease in pulmonary function in this early-SSc cohort. This does not support preliminary data suggestive of a causative role of oesophageal involvement. M. Gilson. European Respiratory Journal. June 18, 2009. (Also see: Pulmonary Fibrosis and Esophageal Involvement) | |
| Pentoxyphylline in association with vitamin E reduces cutaneous fibrosis in systemic sclerosis. Pentoxyphylline and vitamin E might be an alternative therapeutic approach in SSc patients. R. B. Christmann de Souza. (SpringerLink) Clinical Rheumatology. May 26, 2009. (Also see: Skin Fibrosis) | |
| The role of capillaroscopy in differentiation of primary and secondary Raynaud’s phenomenon in rheumatic diseases: a review of the literature and two case reports. In conclusion, capillaroscopy is of crucial importance for the differentiation of primary and secondary RP in rheumatic diseases, and also in differentiation between different forms of connective tissue diseases as well as for their early diagnosis. Sevdalina Nikolova Lambova. (SpringerLink) Rheumatology International. June 23, 2009. (Also see: Nailfold Capillaroscopy) | |
| Efficacy of connective tissue massage and Mc Mennell joint manipulation in the rehabilitative treatment of the hands in systemic sclerosis (SSc). The combination of connective tissue massage, Mc Mennell joint manipulation and home exercise programme is effective in the rehabilitative treatment of SSc hands. This combined treatment may lead to an improvement of hand function and quality of life. Susanna Maddali Bongi. (SpringerLink) Rheumatology International. June 25, 2009. (Also see: Sclerodactyly) | |
| Clinical Correlates of Self-reported Physical Health Status in Systemic Sclerosis. In multivariate analysis, significant clinical predictors of the SF-36 Physical Component Summary score (PCS) were shortness of breath, number of gastrointestinal problems, skin score, swollen joint count, and age. Marie Hudson. Journal of Rheumatology. May 15, 2009 (Also see: About Scleroderma) |
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