| Scleroderma Medical News by Date |
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| May 2007 |
| In vivo study of skin mechanical properties in Raynaud's phenomenon (RP). Mechanical properties of the skin in patients with suspected secondary RP significantly differ from these in patients with primary RP and resemble those in patients with edematous phase of scleroderma. Our findings suggest that the non-invasive measurements of skin elasticity could be helpful in identifying patients with RP at risk of developing SSc. PubMed. Skin Res Technol. 2007 Feb;13(1):91-4. (Also see: Raynaud's Diagnosis ) |
| Therapeutic management of acral manifestations of systemic sclerosis. Acral manifestations of systemic sclerosis include Raynaud's phenomenon, calcinosis cutis, and sclerodactyly. In the later stages of the disease, contractures of the skin and joints as well as obliterative vasculopathy leading to digital ulcers and necrotic lesions may occur. PubMed. Med Klin (Munich). 2007 Mar 15;102(3):209-18. (Also see: Raynaud's, Calcinosis, Sclerodactyly, Digital Ulcers, and Skeletal Involvement: Joint Contractures ) |
| High-dose immunosuppressive therapy and autologous hematopoietic cell transplantation for severe systemic sclerosis: long-term follow-up of the U.S. multicenter pilot study. These are the results of a phase II, single arm study of high-dose immunosuppressive therapy (HDIT) and autologous CD34-selected hematopoietic cell transplantation (HCT) conducted in 34 patients with diffuse cutaneous SSc. PubMed. Blood. 2007 Apr 23. (Also see: Stem Cell Transplant ) |
| Local implantation of autologous mononuclear cells (MNCs) from bone marrow and peripheral blood for treatment of ischaemic digits in patients with connective tissue diseases. Implantation of autologous MNCs from peripheral and bone marrow into the ischaemic digits was very effective in pain-relief and more clinical trials would be warranted to see whether this could be a new treatment modality for angiogenesis in connective tissue diseases as in Buerger's disease. PubMed. Rheumatology (Oxford). 2007 Feb 19. (Also see: Digital Ulcers and Stem Cell Transplants ) |
| A new computerized method for the assessment of skin lesions in localized scleroderma (LS). CSS (computerized skin score) has shown to be a reliable method to assess the skin lesions in patients with LS. It is reproducible, easy to use and, with the support of the CSS software, applicable worldwide. PubMed. Rheumatology (Oxford). 2007 Jan 30. (Also see: Localized Scleroderma ) |
| Werner's Syndrome: A Rare Cause of Hoarseness. A 31-year-old man presented with a 12-year history of hoarseness. Also noted were diabetes mellitus, cataracts, scleroderma-like skin atrophy, osteoporosis, and hypogonadism. A clinical diagnosis of WS was made. PubMed. J Voice. 2007 Jan 20. (Also see: Diseases Similar to Scleroderma: Werner's Syndrome ) |
| En coup de sabre morphea and Parry-Romberg syndrome: a retrospective review of 54 patients. En coup de sabre morphea and Parry-Romberg syndrome frequently coexist and are likely both variants of morphea. Bilateral disease is more common than previously reported. The efficacy of antimalarials and methotrexate in the treatment of these diseases remains unclear. PubMed. J Am Acad Dermatol. 2007 Feb;56(2):257-63. (Also see: En Coup de Sabre and Parry-Romberg Syndrome ) |
| Unilateral limited scleroderma-like changes following formation of an arteriovenous fistula. The arteriovenous fistula for haemodialysis had been formed on the same arm 2 years previously. Tissue hypoxia is believed to be a contributing factor in the pathogenesis of scleroderma, and this case demonstrates scleroderma-like changes in the setting of limb ischaemia. PubMed. Australas J Dermatol. 2007 Feb;48(1):37-9. (Also see: Renal Involvement and Diseases Similar to Scleroderma: Scleroderma-Like ) |
| Radiotherapy for malignancy in patients with scleroderma: The Mayo Clinic experience. The results suggest that although some patients with scleroderma treated with radiation experience considerable toxic effects, the occurrence of Grade 3 or higher toxicity may be less than previously anticipated. PubMed. Int J Radiat Oncol Biol Phys. 2007 Feb 1;67(2):559-67. (Also see: Scleroderma and Cancer ) |
| Associations of breast cancer development in patients with systemic sclerosis: an exploratory study. An older age at diagnosis of systemic sclerosis, a lack of ANA positivity, and the presence of pulmonary fibrosis were more commonly seen in patients with systemic sclerosis who have a diagnosis of breast cancer. PubMed. Clin Rheumatol. 2007 Feb 2. (Also see: Scleroderma and Cancer and Pulmonary Fibrosis ) |
| Penile cutaneous temperature in systemic sclerosis: a thermal imaging study. The results show that penile thermal abnormalities occur in almost all sclerodermic patients. Non-contact thermal imaging not only identifies thermal alterations but also clearly distinguishes between SSc patients and healthy controls and therefore could represent a valuable instrument in identifying early ED (erectile dysfunction) in SSc patients. PubMed. Int J Immunopathol Pharmacol. 2007 January-March;20(1):139-144. (Also see: Sexuality and Scleroderma ) |
| The impact of depression, microvasculopathy, and fibrosis on development of erectile dysfunction in men with systemic sclerosis. Patients with ED had more extended fibrotic changes, which indirectly suggests that fibrosis of the corporal body may play the main role in the pathogenesis of ED in SSc. PubMed. Clin Rheumatol. 2007 Feb 10. (Also see: Sexuality and Scleroderma ) |
| Taxane-induced scleroderma. We report five women who presented with scleroderma due to taxanes, mimicking systemic sclerosis. All five patients had received taxane chemotherapy for the treatment of metastatic breast cancer. Although the mechanisms have not been clarified, it should be noted that taxane is causally involved in the formation of scleroderma-like skin conditions. PubMed Br J Dermatol. 2007 Feb;156(2):363-7. (Also see: Causes of Scleroderma: Drugs and Medications, Cancer and Scleroderma, and Diseases Similar to Scleroderma ) |
| Skin involvement in scleroderma--where histological and clinical scores meet. The histological extent of skin fibrosis correlates closely with the mRSS. Both parameters appeared to regress after HSCT (haematopoietic stem cell transplantation). The extent of TGF-beta signalling activation in SSc skin fibroblasts appears to parallel the severity of disease. PubMed. Rheumatology (Oxford). 2007 Jan 25. (Also see: Skin Fibrosis and Causes of Scleroderma: Molecular Defect ) |
| Genetic Association Studies in Systemic Sclerosis: More Evidence of a Complex Disease. Systemic sclerosis (SSc) clearly falls into the category of complex genetic disease, with well recognized variability in clinical and serological presentation and intricate underlying mechanisms, which involve vascular and immune activation within a fibrotic process. J Rheumatol 2007 May;34:903 Editorial. (Also see: Causes of Scleroderma: Genetics, and Environmental ) |
| Association of Polymorphisms in the IL1B and IL2 Genes with Susceptibility and Severity of Systemic Sclerosis. IL1B and IL2 gene polymorphisms may be involved in susceptibility to SSc. Moreover, the IL2-384-G allele may be a marker for the limited phenotype of SSc. J Rheumatol 2007 May;34:997-1004. (Also see: Causes of Scleroderma: Genetics, and Limited Scleroderma) |
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