| LUNG (PULMONARY): MAIN MENU |
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| Pulmonary Fibrosis |
| This page was written by Shelley Ensz, and has not yet been medically edited. See Disclaimer. |
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| Correlation between Pulmonary Fibrosis and other Diseases / Complications |
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| Correlation of Esophageal and Lung Involvement |
| Prognostic factors for lung function in systemic sclerosis: prospective study of 105 cases. To identify prognostic factors for SSc-ILD and to clarify the possible causative role of manometric esophageal involvement. Only diffuse SSc was predictive of a decrease in pulmonary function in this early-SSc cohort. This does not support preliminary data suggestive of a causative role of oesophageal involvement. M. Gilson. European Respiratory Journal. June 18, 2009. (Also see: Esophageal Involvement) |
| Gastro-Esophageal Reflux and Pulmonary Fibrosis (ILD) in Scleroderma (SSc): A Study Using pH-Impedance Monitoring. SSc patients with ILD have more severe reflux i.e. more reflux episodes and more reflux reaching the proximal esophagus. Savarino E. (PubMed) Am J Respir Crit Care Med. 2008 Dec 18. (Also see: GERD) |
| Characteristics of Patients with Early Systemic Sclerosis and Severe Gastrointestinal Tract Involvement. Our findings strongly suggest the existence of a subgroup of SSc patients with severe GIT involvement in the early stage. Among the Japanese individuals, these patients never developed severe ILD, even though they were classified as having diffuse cutaneous SSc. J Rheumatol 2007;34:2050-5. (Also see: GI Involvement) |
| Clinical features of scleroderma patients with contracture of phalanges (CP). Our study suggested that the presence of CP may be a marker of oesophageal involvement, pulmonary fibrosis and heart involvement. PubMed Clin Rheumatol. 2007 Aug;26(8):1275-7. (Also see: Joint Contractures, Esophageal Involvement,and Cardiac Involvement) |
| Clinical features of scleroderma patients with contracture of phalanges (CP). The study suggested that the presence of CP may be a marker of oesophageal involvement, pulmonary fibrosis and heart involvement. PubMed. Clin Rheumatol. 2006 Dec 15. (Also see: Muscle and Joint Involvement, Esophageal Involvement and Cardiac Involvement) |
| Esophageal Involvement is Correlated with Interstitial Lung Involvement (ILD) in Systemic Sclerosis (SSc) Patients. In our study, 100% of 25 unselected SSc patients showed some degree of GE disease by manometry. A significant correlation was shown between manometric parameters and the reduction of total lung capacity and DLCO. There may be simultaneous involvement in the natural course of the disease or esophageal involvement may favour aspiration phenomena and promote progression of ILD. E. Vesprini. FRI0104 EULAR 2005. (Also see: What is Scleroderma?, Esophageal Involvement, and Aspiration Pneumonia) |
| Prevalence of gastroesophageal reflux in end-stage lung disease candidates for lung transplant. Gastroesophageal reflux is highly prevalent in end-stage lung disease patients who are candidates for lung transplantation. Further investigation is needed to study the prevalence of gastroesophageal reflux after lung transplantation and its contribution to chronic allograft dysfunction. PubMed. Ann Thorac Surg. 2005 Oct;80(4):1254-60. (Also see: GERD) |
| Correlation of Pulmonary Fibrosis and Pulmonary Hypertension |
| Pulmonary Arterial Hypertension (PAH) and Severe Pulmonary Fibrosis in Systemic Sclerosis Patients with a Nucleolar Antibody. Scleroderma-specific autoantibodies and the FVC%/DLCO% ratio are helpful in determining whether a patient has PAH alone, PAH along with pulmonary fibrosis, or secondary PAH from chronic hypoxia with severe pulmonary fibrosis. J Rheumatol 2007;34:2230-5. (Also see: Pulmonoary Hypertension and Antibodies) |
| High-Resolution Chest CT Findings Do Not Predict the Presence of Pulmonary Hypertension in Advanced Idiopathic Pulmonary Fibrosis. Chest CT-determined fibrosis score, ground-glass opacity score, honeycombing score, total profusion score, diameter of the main pulmonary artery, and the ratio of the pulmonary artery to aorta diameter did not differ between those with and without PH. There was no significant correlation between mean pulmonary artery pressure and any of the chest CT-determined measures. Chest. 2007; 132:773-779. (Also see: Pulmonary Hypertension) |
| Pulmonary Hypertension (PH) in Patients With Interstitial Lung Diseases. In the lungs, parenchymal and vascular remodelling share pathomechanisms that may explain the relatively high prevalence (30-40%) of pulmonary hypertension (PH) in interstitial lung disease (ILD) patients. Behr. J. (PubMed) Eur Respir J. 2008 Jun;31(6):1357-67. (Also see: Pulmonary Fibrosis) |
| Prevalence and Characteristics of Moderate to Severe Pulmonary Hypertension in Systemic Sclerosis with and without Interstitial Lung Disease. Prevalence of moderate to severe PH was similar in SSc patients with and those without ILD. In patients with ILD, a lower PaO2 was the unique independent indicator associated with PH. In some patients with severe ILD, PH was out of proportion to the degree of fibrosis. J Rheumatol 2007May;34:1005-11. (Also see: Pulmonary Hypertension) |
| Correlation of Pulmonary Fibrosis and Heart Complications |
| The prevalence of coronary artery disease (CAD) in end-stage pulmonary disease: Is pulmonary fibrosis a risk factor? There is significantly more CAD in lung-transplantation candidates with lung fibrosis as compared to those with emphysema, despite the fact that smoking was much more prevalent in the emphysema patients. These results suggest that the inflammatory process in lung fibrosis may involve the coronary arteries as a part of a systemic inflammation rather than an idiopathic fibrotic disease confined to the lungs. G. Izbicki. Respiratory Medicine Volume 103, Issue 9, Pages 1346-1349. (September 2009) (Also see: Cardiac Involvement) |
| Double Threat: Deadly Lung Disease Also Linked to Heart Attacks. Patients with idiopathic pulmonary fibrosis (IPF) are three times as likely to experience severe coronary events—including heart attacks—than people without the disease. (Newswise) American Thoracic Society. 12/03/08. |
| The Association Between Idiopathic Pulmonary Fibrosis and Vascular Disease. People with idiopathic pulmonary fibrosis have an increased risk of vascular disease in comparison to the general population. Richard B Hubbard. Am. J. Respir. Crit. Care Med. August 28, 2008. (Also see: Cardiac Involvement) |
| Relationship Between Lung and Heart Involvement and Cardiopulmonary Functional Status in Patients with Systemic Sclerosis (SSc). According to our results, presence of tricuspid pressure gradient and high right ventricle systolic pressure were the most important factors that predict worsening of cardiopulmonary functional status in patients with SSc. M. B. Zlatanovic. SAT0264 EULAR 2006. (Also see: Cardiac Involvement) |
| Cardiopulmonary Manifestations in Systemic Sclerosis (SSc) - Correlation with Disease Duration and the Extent of Skin Involvement. Interstitial pulmonary fibrosis in patients with SSc causes restrictive lung disease and progresses to severe lung damage and immunoinflammatory heart damage leading to ventricular diastolic dysfunction. B. N. Stamenkovic. AB0291 EULAR 2006. (Also see: Cardiac Involvement and Pulmonary Hypertension) |
| Correlation of Pulmonary Fibrosis and Connective Tissue Disease |
| Ascertainment of collagen vascular disease in patients presenting with interstitial lung disease.Unrecognized collagen vascular disease may be more common than previously appreciated among patients referred with ILD. High titer ANA and an elevated CPK or aldolase are associated with a CVD diagnosis in this referral population.Shikhaa Mittoo. Journal of Respiratory Medicine. Volume 103, Issue 8, Pages 1152-1158. (August 2009). |
| Interstitial lung disease (ILD) in polymyositis and dermatomyositis (PM/DM): Longitudinal evaluation by pulmonary function and radiology. ILD associated with PM/DM is in most cases mild, chronic, and has a nonprogressive course during immunosuppressive treatment. Myositis patients with ILD need careful evaluation of clinical features as well as Pulmonary function test and radiologic features during followup. (Wiley Interscience) Arthritis Care & Research 25 April 2008 (Also see: DM/PM). |
| Collagen vascular diseases and lung: Characterization of the outpatients with interstitial lung disease. The interstitial lung diseases associated with collagen vascular disease represent an important group of patients. The evolution is usually better than the one of the idiopathic forms. PubMed. Rev Port Pneumol. 2005 Nov;11(6 Suppl 1):26-7. |
| Comparison of disease progression and mortality of connective tissue disease-related interstitial lung disease (CTD-ILD) and idiopathic interstitial pneumonia (IIP). Contrary to expectation, CTD-ILD compared with IIP appears to be associated with a worse prognosis when adjusted for age. A higher fibrotic score is suggestive of decreased survival. PubMed. Arthritis Rheum. 2005 Aug 15;53(4):549-57. |
| Interstitial lung disease in connective tissue disorders. The prognosis of connective tissue associated ILD is better than that of idiopathic ILD. The treatment requires corticosteroids and/or immunosuppressants, depending on the nature of the associated connective tissue disease and ILD progression. PubMed. Rev Pneumol Clin. 2005 Jun;61(3):211-9. |
| Correlation of Pulmonary Fibrosis and Cancer |
| Associations of breast cancer development in patients with systemic sclerosis: an exploratory study. An older age at diagnosis of systemic sclerosis, a lack of ANA positivity, and the presence of pulmonary fibrosis were more commonly seen in patients with systemic sclerosis who have a diagnosis of breast cancer. PubMed. Clin Rheumatol. 2007 Feb 2. (Also see: Scleroderma and Cancer) |
| Does interstitial lung disease predispose to lung cancer? Idiopathic pulmonary fibrosis, systemic sclerosis, and certain pneumoconioses are associated with an independent increased risk of lung cancer; however, a unifying pathogenetic mechanism to explain the causality of this association has not been described. PubMed. Curr Opin Pulm Med. 2005 Sep;11(5):431-7. (Also see: Scleroderma and Cancer) |
| Correlation of Pulmonary Fibrosis and Thyroid Disease |
| Serum Endostatin Level in Patients with Systemic Sclerosis: Relationship to Thyroid Function, Skin Score and Pulmonary Fibrosis. Hypothyroidism should be considered as a endostatin-modulating factor in evaluation of fibrotic activity in the SSc patients. The role of endostatin in control of angiogenesis in SSc patients remains unknown. E. J. Kucharz. FRI0333 EULAR 2004. (Also see: Thyroid Disease) |
| Patient Stories |
| Brenda M: Primary Biliary Cirrhosis (PBC), Fibromyalgia, Pulmonary Fibrosis, and Sjogren's Syndrome In 1965, when I was twenty-six, I went to work for a firm of electro-platers, which was mainly aircraft work... |
| Debbie G: CREST, Lupus, Interstitial Lung Disease and Pulmonary Hypertension It has been a very long and bumpy road at times but somehow through all the hospital visits and other illnesses I have managed to stay ahead of the game by a step or two... |
| Don Alfera: CREST, Pulmonary Fibrosis and Sjögren's I entitled this "My Time So Far" since this has been a journey unlike any that I could have ever tried to imagine in my life... |
| Tony B: Systemic Scleroderma with Pulmonary Fibrosis, Pulmonary Hypertension and Raynaud's It has taken me some time to come to terms with this disease... |
| Judy Tarro: Diffuse Scleroderma, Sjogren's, Pulmonary Fibrosis and Pulmonary Hypertension The best we can figure, I was diagnosed with diffuse scleroderma in 1956. I am now webmaster of SD World... |
