| Eye Involvement |
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| These symptoms may sometimes occur in systemic sclerosis (scleroderma). Scleroderma (SD) affects everyone differently. Just because something is listed here does not mean it is caused by scleroderma nor that an individual scleroderma patient will ever experience it. See Disclaimer. |
| Normal Tension Glaucoma (NTG) |
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| Normal Tension Glaucoma (NTG) Overview |
| Regular glaucoma is when the optic nerve is damaged by high pressure inside of the eye. It can cause permanent vision loss. Normal Tension Glaucoma (NTG) is when the optic nerve is damaged even though the pressure inside of the eye is normal. |
| What is Glaucoma? Glaucoma is a group of eye diseases that gradually steals sight without warning and often without symptoms. Glaucoma Research Foundation. |
| Type Abnormalities in Patients with Systemic Sclerosis. In the two groups under study, intraocular pressure was measured within normal limits. However, glaucomatous type abnormalities were more frequent in patients with SSc compared to the control group. Such abnormalities may be atributed to the vasculopathy that is observed in patients with SSc, affecting therefore and the vessels of the optic disc. A.A. Drosos. [FRI0347] EULAR 2006. |
| Normal-Tension Glaucoma. Normal-tension glaucoma (also called low-tension glaucoma) is a unique condition in which optic nerve damage and vision loss have occurred despite a normal pressure inside the eye. Although its cause is not completely understood, normal-tension glaucoma is generally believed to occur either because of an unusually fragile optic nerve that can be damaged despite a normal pressure inside the eye or because of reduced blood flow to the optic nerve. WebMD. |
| Changes in Eye Pressure and Anterior Chamber Depth With Oral Endothelin Antagonist Therapy: Clinical Trials. We hypothesize that the rate of structural damage to the nerve fiber layer (NFL), a feature of glaucoma, is higher in patients with pulmonary hypertension (PH) than expected in healthy populations lacking this disease. This study is currently recruiting participants. ClinicalTrials.gov University of Colorado at Denver and Health Sciences Center (Also see: Pulmonary Hypertension) |
| Normal Tension Glaucoma and and Systemic Sclerosis (Scleroderma) |
| A significant increase of normal tension glaucoma (NTG) has been discovered in patients with systemic scleroderma. In a 2003 study of 88 scleroderma patients in France, 10 of the patients were found to have NTG, compared to none of the controls. |
| Increased Incidence of Normal Tension Glaucoma (NTG) in Systemic Sclerosis (SSc). NTG is dramatically increased in SSc compared to patients with osteoarthritis. These results might have important clinical implications in SSc and justify long-term follow-up to assess the possible ophthalmological risk. They are also consistent with the vascular pathogenic hypothesis for NTG. Y. Allanore. FRI0077 EULAR 2003. |
| Glaucomatous Type Abnormalities in Patients with Systemic Sclerosis. Glaucomatous type abnormalities were more frequent in patients with systemic sclerosis (SSc) compared to the control group. Such abnormalities may be attributed to the vasculopathy that is observed in patients with SSc, affecting the vessels of the optic disc. G. Kitsos. FRI0347 EULAR 2006. (Also see: Vasculitis) |
| Ocular Glaucomatous Abnormalities and Systemic Sclerosis (Scleroderma) |
| Increased prevalence of ocular glaucomatous abnormalities in systemic sclerosis. Ocular abnormalities suggesting glaucomatous neuropathy without ocular hypertension were dramatically more prevalent in patients with SSc. These abnormalities seem to be mild but justify long term follow up. They are consistent with the vascular pathogenic hypothesis for NTG (normal tension glaucoma). PubMed. Ann Rheum Dis. 2004 Oct;63(10):1276-8. |
| Symptoms and Diagnosis of Normal Tension Glaucoma |
| Symptoms of Normal Tension Glaucoma. Regular eye examinations with an ophthalmologist are important to screen for optic nerve damage and vision loss despite a normal eye pressure. eMedicine. |
| Antiphospholipid antibodies in patients with sensorineural hearing loss. Sensorineural hearing loss can be associated with autoimmune diseases and the presence of antiphospholipid antibodies. Our data suggest that antibodies against beta(2)-glycoprotein seem to coincide with an acute event, such as sudden sensorineural hearing loss, whereas antibodies against phosphatidylserine IgG are detectable in the prolonged sequel, such as in patients with progressive sensorineural hearing loss and normal tension glaucoma. PubMed. Eur Arch Otorhinolaryngol. 2005 Feb 25. (Also see: Antiphospholipid Syndrome and Ear Involvement) |
| Treatments of Normal Tension Glaucoma |
| Effect of sex hormones on experimental autoimmune uveoretinitis (EAU). The data support the hypothesis that sex hormones may affect autoimmune diseases by inducing changes in the cytokine balance. This suggests that sex hormone therapy could be considered as an adjunct to anti-inflammatory agents to treat ocular autoimmune diseases in humans. PubMed. Immunol Invest. 2003 Nov;32(4):259-73. |
| Retinal findings in systemic sclerosis: a comparison with nailfold capillaroscopic patterns. Retinal abnormalities are often seen in patients with SSc and they may reflect the vascular changes characteristic of SSc. However, retinal changes may differ in quality from the changes of nailfold capillaries. PubMed. Ann Rheum Dis 2003 Mar;62(3):204-7. (Also see: Types of Scleroderma) |
Hello, I am Dr. Liz Irvin, your ISN Guide to Eye Involvement.