Graft-versus-Host Disease (GVHD) |
| Author: Shelley Ensz. Scleroderma is highly variable. See Types of Scleroderma. Read Disclaimer |
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Overview of Graft-versus-Host Disease (GVHD) |
| Graft-versus-Host Disease (GVHD) is an autoimmune response to foreign cells, such as from skin grafting, bone marrow transplants, stem cell transplants, blood transfusions, or organ transplants. |
| What is GVHD? When you receive a donor's stem cells (the “graft”), their job is to recreate the donor's immune system in your body (the “host”). Graft versus host disease (GVHD) is the term used when this new immune system attacks your body. Your donor's cells see your body as “foreign” and attack it––causing damage. GVHD most commonly affects the skin, liver, and gastrointestinal tract. National Institutes of Health (NIH). |
| Graft-versus-host disease (GVHD) related polymyositis. Chronic GVHD sometimes mimics autoimmune diseases. We report the case of a 39-year-old patient who presented atypical polymyositis without elevated creatinine phosphokinase, related to a chronic GVHD following interruption of immunosuppressive treatment. (SpringerLink) H. Maillard – Lefebvre. January 13 2010. (Also see: Research on Polymyositis). |
Causes of Graft-versus-Host Disease (GVHD) |
| Graft-versus-Host Disease - Causes. Graft-versus-host disease (GVHD) is a complication that can occur after a stem cell or bone marrow transplant in which the newly transplanted material attacks the transplant recipient's body. MedlinePlus, 2010. |
Diagnosis of Graft-versus-Host Disease (GVHD) |
| Cutaneous Chronic Graft-Versus-Host Disease. Cutaneous involvement is the most frequent manifestation of chronic graft-versus-host disease (cGVHD). Wiley Online Library, 09/06/2013. |
| Bullous scleroderma-like changes in chronic graft-versus-host disease. Chronic cutaneous GVHD is categorized according to the type of skin lesions into lichenoid and sclerodermoid variants, but bullous scleroderma-like changes are exceptional. PubMed, J Eur Acad Dermatol Venereol 17(2):200-3. |
Treatments for Graft-versus-Host Disease (GVHD) |
| Graft-versus-host disease of the skin and adjacent mucous membranes. The incidence of GVHD has been rising in the last decade and care and therapy of patients requires an interdisciplinary approach with dermatology in a key position. Wiley. Journal of The German Society of Dermatology, 30 May 2013. |
| A case of cutaneous lichen sclerosus et atrophicus (LSA) effectively treated by extracorporeal photochemotherapy (ECP). The fact that ECP is effective in LSA, graft-versus-host disease (GVHD), erosive lichen planus, and scleroderma strengthen the hypothesis that there is a common link between these four conditions. Wiley. Photodermatology, Photoimmunology & Photomedicine, 7 May 2013. (Also see: Lichen Sclerosus) |
Patient Stories for Graft-versus-Host Disease (GVHD) |
| Blog: Jackie Sue We Love You. Jackie passed away on November 30th, 2011. Jackie had GVHD. The blog covered her progress after her mini-allo MUD transplant. Her transplant was the first one to be performed by the Mayo Clinic. Bruce and Jackie. (Also see: Graft vs. Host Disease, GVHD) |
| Klaas: Scleroderma Graft-vs-Host Disease (GVHD) So I would like to know if, and when, I will be able to walk again... |
| (Spanish/Español) Klaas: Sclerodermia da GVHD Essiste un modo per capire se ci sono delle speranze e quali sono... |
| (Italiano) Fabiola: Paziente Affetta da Sclerodermia Morphea Dopo 5 anni si e' svegliata una sclero conseguenza pero' della GVHD (Graft Versus Host Disease) che viene dopo il trapianto di midollo... |
Research for Graft-versus-Host Disease (GVHD) |
| Stem Cell Finding Could Help Reduce Transplant Rejection. A new study involving a type of stem cells from the lungs of transplant patients demonstrates for the first time that these progenitor cells reside in adult organs and are not derived from bone marrow, which leads to the possibility that the cells may be able to help with the rejection of donated organs. Newswise. University of Michigan Health System. 03/08/07. (Also see: Pulmonary Fibrosis) |
