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| Antibodies in Lupus | |||
| Interferon-induced versus chemokine transcripts as lupus biomarkers. Chemokines are among the interferon-inducible genes, and new data support an association between expression of chemokines and both lupus disease activity and organ damage. M K Crow. Arthritis Research & Therapy 2008, 10:126. | |||
| Antiphospholipid antibody syndrome and autoimmune diseases. Evidence is growing that antiphospholipid antibodies may have a pathogenic role in pulmonary hypertension and accelerated atherosclerosis of autoimmune diseases. (PubMed) Hematol Oncol Clin North Am. 2008 Feb; 22(1):53-65. (Also see: Antibodies, PH,and Cardiac) | |||
| New biomarkers for lupus found. Mishra said microRNAs are a class of small chains of ribonucleic acid that have important regulatory functions in the body, particularly in suppressing genes. "We are the first to show that these micro-RNAs are a problem in human lupus." EurekAlert! 11/10/06. | |||
| Quantitation of autoantibodies in systemic autoimmune diseases: clinically useful? Treatment based on changes in levels of the respective autoantibodies only seems at present not justified, in view of the toxicity of currently available immunosuppressive regimens. (Sage Journals OnLine) Lupus, Vol. 15, No. 7, 397-402 (2006) (Also see: Antibodies) | |||
| Yale scientists identify structure for RNA quality control. A report by Yale scientists in the journal Cell sheds new light on how the protein Ro, a major autoantigen in patients with autoimmune disease, recognizes misfolded RNAs, creating a RNA quality control system for cells. Medical News Today. 06/02/05. (Also see: Sjogren's Syndrome) | |||
| Autoantibody explosion in systemic lupus erythematosus: More than 100 different antibodies found in SLE patients. SLE is the autoimmune disease with the largest number of detectable autoantibodies. Their production could be antigen-driven, the result of polyclonal B cell activation, impaired apoptotic pathways, or the outcome of idiotypic network dysregulation. PubMed. Semin Arthritis Rheum. 2004 Oct;34(2):501-37. | |||
| The immune response to cell death in SLE. Since circulating DNA in the form of immune complexes can play a role in lupus pathogenesis, these findings suggest that the generation and clearance of dead cells are important events that may underlie autoimmunity in this disease and may be targeted for therapy. PubMed. Autoimmun Rev. 2004 Nov;3(7-8):500-4. | |||
| Anti-Lactoferrin | |||
| Anti-lactoferrin antibodies in patients with connective tissue diseases. Patients with connective tissue diseases are known to develop multiple auto-antibodies; anti-lactoferrin antibodies mainly of IgG1 isotype can also be found in patients with rheumatoid arthritis and more often in patients with systemic lupus erythematosus. PubMed. Folia Med (Plovdiv). 2003;45(4):25-30. (Also see: Rheumatoid Arthritis) | |||
| C Reactive Protein (Anti-CRP) | |||
| Autoantibodies Against C-Reactive Protein: Clinical Associations in Systemic Lupus Erythematosus and Primary Antiphospholipid Syndrome. We observed that the presence of these antibodies was associated with lupus nephritis and with clinical features of the APS in patients with lupus and non-lupus patients. J Rheumatol 2006;33:1980-6. (Also see: APS and Antibodies) | |||
| Serum levels of autoantibodies against monomeric C-reactive protein are correlated with disease activity in systemic lupus erythematosus. This indicates that anti-CRP antibodies might have biological functions of pathogenetic interest in SLE. Arthritis Res Ther 2004, 6:R87-R94. | |||
| Serum levels of autoantibodies against monomeric C-reactive protein are correlated with disease activity in systemic lupus erythematosus. This indicates that anti-CRP antibodies might have biological functions of pathogenetic interest in SLE. Arthritis Res Ther 2004, 6:R87-R94. |
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