| Autoantibodies in Scleroderma |
| This page was written by Shelley Ensz and has not yet been medically edited. See disclaimer. |
|
|
| Overview of Antibody Testing |
| Specialized blood tests such as antinuclear antibody (ANA) tests are sometimes useful in the diagnosis or categorization of both localized and systemic scleroderma, as well as overlapping or other autoimmune diseases. |
| Scleroderma - A Simple Blood Test Could Save Lives. “Diagnosis can be helped by an anti nuclear antibody (ANA) blood test. If positive then early treatment may prevent the condition from progressing, especially if the lungs are involved. Once a diagnosis of scleroderma is made, patients can be closely followed in specialist centres so that complications are detected as soon as possible.” Professor Christopher Denton. Medical News Today. 11/06/09. (Also see: ANA) |
| Antibodies as predictors of complex autoimmune diseases. Clinicians should be aware that the detection of antibodies should not automatically mean that a patient will definitely become ill, but would rather give a percentage of risk for autoimmune disease over subsequent months or years. Vojdani. Int J Immunopathol Pharmacol. 2008 Apr-Jun;21(2):267-78. (PubMed). (Also see: Autoimmunity) |
| What Is An ANA (antinuclear antibody) Test? Antibodies are proteins, produced by white blood cells, which normally circulate in the blood to defend against foreign invaders such as bacteria, viruses, and toxins. Autoantibodies, instead of acting against foreign invaders as normal antibodies do, attack the body's own cells. Antinuclear antibodies are a unique group of autoantibodies that have the ability to attack structures in the nucleus of cells. About.com.arthritis. C. and R. Eustice. Updated: 50/25/06. |
| Antibody Patterns. To learn about antibodies associated with scleroderma and other rheumatic diseases, click on "Rheumatic" in the navigation bar. Antibody Patterns. |
| Antibodies and Complement in Myopathies and Neuromuscular Disorders. Very technical medical resource. Neuromuscular Disease Center, Washington University. |
| Comprehensive Scleroderma Antibodies Panel. Introducing a comprehensive serologic assessment for Systemic Sclerosis (Scleroderma— SSc). RDL Reference Laboratory. |
| Quantitation of autoantibodies in systemic autoimmune diseases: clinically useful? Treatment based on changes in levels of the respective autoantibodies only seems at present not justified, in view of the toxicity of currently available immunosuppressive regimens. (Sage Journals OnLine) Lupus, Vol. 15, No. 7, 397-402 (2006) (Also see: Lupus) |
| Autoimmune Disease? Get Paid for Your Antibodies! |
| Access Biologicals’ Specialty Antibody Donors. If you have been diagnosed with and are being treated for any autoimmune disease, you may be eligible to receive up to $500 per plasma donation, as long as your antibody levels are high. For U.S. residents who weigh at least 110 lbs and are at least 18 years of age. Access Biologicals. Posted 06-12-07. |
| ESR: Erythrocyte Sedimentation Rate |
| ESR: Erythrocyte Sedimentation Rate. There are different methods of obtaining the SED rate--such as Westergren, Cutler, Wintrobe, and Smith--and what is considered normal will depend on the method used. This test can be used to monitor inflammatory or cancerous diseases. It is a screening test, which means it cannot be used to diagnose a specific disorder. Medline Plus. |
| Antibodies in Systemic Scleroderma |
|
|
| Antibodies in Localized Scleroderma (Linear and Morphea) |
| Serum Autoantibodies and their Clinical Associations in Patients with Childhood and Adult Onset Linear Scleroderma. Childhood onset Linear Scleroderma is similar to adult onset disease in regard to the frequency of serum autoantibodies. Thaschawee Arkachaisri. 289/289 ACR 2006. (Also see: Linear Scleroderma) |
| Antihistone antibodies (AHAs) in linear scleroderma variants. AHAs, which traditionally are markers for drug-induced lupus, may also be linked to linear scleroderma. The AHA titers may be related to the extent of involvement as well as disease activity. PubMed. Int J Dermatol. 2006 Nov;45(11):1296-9. (Also see: Linear Scleroderma) |
| TNF and IL-13: Serum levels of tumor necrosis factor and interleukin-13 are elevated in patients with localized scleroderma. These results suggest that TNF and IL-13 may be associated with the development of LSc. PubMed. Dermatology. 2003;207(2):141-7. (Also see: Linear and Morphea) |
| Antinuclear Antibodies |
| Novel Autoantibody to Cu/Zn Superoxide Dismutase in Patients with Localized Scleroderma. IgG or IgM anti-Cu/Zn SOD antibody was detected in the serum of 89% of localized scleroderma patients, especially 100% of patients with generalized morphea, the severest form of localized scleroderma, but was positive only in the serum of less than 15% of patients with other autoimmune disorders, including systemic sclerosis, systemic lupus erythematosus, dermatomyositis, and autoimmune bullous disorders. Masaki Nagai. Journal of Investigative Dermatology (2004) 122, 594–601. (Also see: Generalized Morphea) |
| Antinucleosome |
| Antinucleosome antibody is a major autoantibody in localized scleroderma. Although antinucleosome antibody was not specific to localized scleroderma, its high prevalence in localized scleroderma indicates that antinucleosome antibody is a major autoantibody in this disease. PubMed. Br J Dermatol. 2004 Dec;151(6):1182-8. (Also see: Localized Scleroderma) |
| Antibodies in Juvenile Scleroderma |
| Autoantibodies to Beta Adrenoreceptors in Patients with Juvenile Scleroderma. Further follow up investigations are necessary to find out whether ABâ-1 could serve as an early predictor of scleroderma cardiac lesions in the pre-clinical stage of the disease. M. K. Osminina. THU0095 EULAR 2004. (Also see: Cardiac Involvement, and Juvenile Scleroderma) |
| Lupus and Antibodies |
| Antibodies in Lupus. There are over 100 antibodies associated with lupus. ISN. |
| Sjogren's Syndrome and Antibodies |
| Sjogren's Syndrome Diagnosis. ISN. |
| Thyroid Disease and Antibodies |
| Thyroid Disease and Antibodies. ISN. |
