| Systemic Sclerosis: Scleroderma in Overlap, MCTD, UCTD |
| This page was written by Shelley Ensz and has not yet been medically edited. See Disclaimer. |
| Shared Autoimmunity |
| Shared Autoimmunity is a rather loose term. It variously refers to autoantibodies, symptoms, or presence of autoimmune diseases within the same patient or within several or more members of the same family. |
| High Incidence of Celiac Disease in Patients with Systemic Sclerosis (SSc). Our data show an increased prevalence of celiac disease in patients with SSc. E. Rosato. J. Rheum. March 30 2009. (Also see: Celiac Disease) |
| Polymyalgia rheumatica (PMR) can be distinguished from late onset rheumatoid arthritis (RA) at baseline: results of a 5-yr prospective study. Our longitudinal follow-up data were consistent with RF negative late onset RA being a separate disease entity to PMR despite some phenotypic and immunogenetic similarities at disease onset. C. T. Pease. Rheumatology Advance Access. November 2, 2008. (Also see: Rheumatoid Arthritis) |
| Overlap syndromes in the context of shared autoimmunity. "Shared autoimmunity" is the term being used for the presence of autoimmune rheumatic diseases in several members of the same family, the concurrence of autoimmune rheumatic with non-rheumatic diseases in relatives of patients, the presence of autoantibodies in sera from healthy relatives of autoimmune-disease patients, the development of two or more autoimmune rheumatic diseases in one patient and the interplay of genetic and environmental factors leading to the presence of several autoimmune disease and/or their autoantibodies in families. PubMed. Autoimmunity. 2005 May;38(3):219-23. (Also see: Causes of Scleroderma: Genetics) |
| Immunogenetic mechanisms for the coexistence of organ-specific and systemic autoimmune diseases. Both types of autoimmune diseases may coexist in the same patient, either sequentially or concurrently, sustained by the presence of autoantibodies directed against the corresponding autoantigens. Journal of Autoimmune Diseases 2008, 5:1. |
| Development of Polymyalgia Rheumatica in Patients with Scleroderma. Systemic sclerosis (SSc) and polymyalgia rheumatica (PMR) are uncommon but not rare rheumatic diseases. The various musculoskeletal symptoms that accompany SSc can make the recognition of PMR challenging in these patients. J Rheumatol 2006 June;33:1206. Letters. (Also see: Renal Involvement) |
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